DISEASES

Disease-gene associations mined from literature

Literature on H3-5

H3-5 [ENSP00000339835]

Histone H3.3C; Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Hominid-specific H3.5/H3F3C preferentially colocalizes with euchromatin, and it is associated with actively transcribed genes.

Synonyms:  H3-5,  H3F3C,  Q6NXT2,  H3F3Cp,  hH3F3C ...

Linkouts:  STRING  Pharos  UniProt