DISEASES

Disease-gene associations mined from literature

Literature on SPAG9

SPAG9 [ENSP00000262013]

C-Jun-amino-terminal kinase-interacting protein 4; The JNK-interacting protein (JIP) group of scaffold proteins selectively mediates JNK signaling by aggregating specific components of the MAPK cascade to form a functional JNK signaling module . Isoform 5 may play a role in spermatozoa-egg- interaction . Regulates lysosomal positioning by acting as an adapter protein which links PIP4P1-positive lysosomes to the dynein-dynactin complex .

Synonyms:  SPAG9,  SPAG9p,  hSPAG9,  A0A087X2D8,  D6RHI8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM