DISEASES

Disease-gene associations mined from literature

Literature on DLG2

DLG2 [ENSP00000365272]

Disks large homolog 2; Required for perception of chronic pain through NMDA receptor signaling. Regulates surface expression of NMDA receptors in dorsal horn neurons of the spinal cord. Interacts with the cytoplasmic tail of NMDA receptor subunits as well as inward rectifying potassium channels. Involved in regulation of synaptic stability at cholinergic synapses. Part of the postsynaptic protein scaffold of excitatory synapses (By similarity).

Synonyms:  DLG2,  DLG2p,  hDLG2,  A0A3B3ISW2,  A0A3B3ITF1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM