Literature on NCKAP1L
NCKAP1L [ENSP00000293373]
Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton (Probable). Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages . Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells (By similarity). Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin . Also involved in mechanisms WAVE-independent to regulate myosin and actin polymerization during neutrophil chemotaxis . ECO:0000269|PubMed:16417406, ECO:0000269|PubMed:17696648,
Synonyms: NCKAP1L, NCKAP1Lp, hNCKAP1L, F8W050, P55160 ...