DISEASES

Disease-gene associations mined from literature

Literature on EIF2S2

EIF2S2 [ENSP00000364119]

Eukaryotic translation initiation factor 2 subunit 2; eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. This complex binds to a 40S ribosomal subunit, followed by mRNA binding to form a 43S preinitiation complex. Junction of the 60S ribosomal subunit to form the 80S initiation complex is preceded by hydrolysis of the GTP bound to eIF-2 and release of an eIF-2-GDP binary complex. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must exchange with GTP by way of a reaction catalyzed by eIF-2B.

Synonyms:  EIF2S2,  EIF2S2p,  hEIF2S2,  P20042,  Q6IBR8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM