DISEASES

Disease-gene associations mined from literature

Literature on STX12

STX12 [ENSP00000363054]

Syntaxin-12; SNARE that acts to regulate protein transport between late endosomes and the trans-Golgi network. The SNARE complex containing STX6, STX12, VAMP4 and VTI1A mediates vesicle fusion (in vitro) (By similarity). Through complex formation with GRIP1, GRIA2 and NSG1 controls the intracellular fate of AMPAR and the endosomal sorting of the GRIA2 subunit toward recycling and membrane targeting (By similarity); Belongs to the syntaxin family.

Synonyms:  STX12,  STX12p,  hSTX12,  B1AJQ6,  Q86Y82 ...

Linkouts:  STRING  Pharos  UniProt  OMIM