DISEASES

Disease-gene associations mined from literature

Literature on UBE2C

UBE2C [ENSP00000348838]

Ubiquitin-conjugating enzyme E2 C; Accepts ubiquitin from the E1 complex and catalyzes its covalent attachment to other proteins. In vitro catalyzes 'Lys-11'- and 'Lys-48'-linked polyubiquitination. Acts as an essential factor of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated ubiquitin ligase that controls progression through mitosis. Acts by initiating 'Lys-11'-linked polyubiquitin chains on APC/C substrates, leading to the degradation of APC/C substrates by the proteasome and promoting mitotic exit. ECO:0000269|PubMed:18485873, ECO:0000269|PubMed:19820702, ECO:0000269|PubMed:19822757, ECO:0000269|PubMed:20061386,

Synonyms:  UBE2C,  UBE2Cp,  hUBE2C,  A0A087WVK1,  A0A0A0MSE8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM