DISEASES

Disease-gene associations mined from literature

Literature on ARHGAP10

ARHGAP10 [ENSP00000336923]

Rho GTPase-activating protein 10; GTPase activator for the small GTPases RhoA and Cdc42 by converting them to an inactive GDP-bound state. Essential for PTKB2 regulation of cytoskeletal organization via Rho family GTPases. Inhibits PAK2 proteolytic fragment PAK-2p34 kinase activity and changes its localization from the nucleus to the perinuclear region. Stabilizes PAK-2p34 thereby increasing stimulation of cell death (By similarity).

Synonyms:  ARHGAP10,  A0A2X0SFB3,  A1A4S6,  H0Y8W5,  A1A4S6p ...

Linkouts:  STRING  Pharos  UniProt  OMIM