DISEASES

Disease-gene associations mined from literature

Literature on DYNC1I1

DYNC1I1 [ENSP00000320130]

Cytoplasmic dynein 1 intermediate chain 1; Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCNT1. May play a role in mediating the interaction of cytoplasmic dynein with membranous organelles and kinetochores.

Synonyms:  DYNC1I1,  DYNC1I1p,  hDYNC1I1,  A0A0A0MTG2,  A4D1I7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM