DISEASES

Disease-gene associations mined from literature

Literature on HK2

HK2 [ENSP00000290573]

Hexokinase-2; Catalyzes the phosphorylation of hexose, such as D-glucose and D-fructose, to hexose 6-phosphate (D-glucose 6-phosphate and D- fructose 6-phosphate, respectively) (PubMed:23185017, PubMed:26985301, PubMed:29298880). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate . Plays a key role in maintaining the integrity of the outer mitochondrial membrane by preventing the release of apoptogenic molecules from the intermembrane space and subsequent apoptosis . ECO:0000269|PubMed:23185017, ECO:0000269|PubMed:26985301,; Belongs to the hexokinase family.

Synonyms:  HK2,  HK2p,  hHK2,  E9PB90,  P52789 ...

Linkouts:  STRING  Pharos  UniProt  OMIM