DISEASES

Disease-gene associations mined from literature

Literature on SETD6

SETD6 [ENSP00000219315]

N-lysine methyltransferase SETD6; Protein-lysine N-methyltransferase. Monomethylates 'Lys-310' of the RELA subunit of NF-kappa-B complex, leading to down-regulate NF- kappa-B transcription factor activity . Monomethylates 'Lys-8' of H2AZ (H2AZK8me1) . Required for the maintenance of embryonic stem cell self-renewal (By similarity). ; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.

Synonyms:  SETD6,  SETD6p,  hSETD6,  C9JCR1,  E9PC53 ...

Linkouts:  STRING  Pharos  UniProt