DISEASES

Disease-gene associations mined from literature

Literature on FBXL7

FBXL7 [ENSP00000423630]

F-box/LRR-repeat protein 7; Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex . During mitosis, it mediates the ubiquitination and subsequent proteasomal degradation of AURKA, causing mitotic arrest (By similarity). It also regulates mitochondrial function by mediating the ubiquitination and proteasomal degradation of the apoptosis inhibitor BIRC5 .

Synonyms:  FBXL7,  FBXL7p,  hFBXL7,  J3KNM9,  Q9UJT9 ...

Linkouts:  STRING  Pharos  UniProt  OMIM