DISEASES

Disease-gene associations mined from literature

Literature on AQP11

AQP11 [ENSP00000318770]

Aquaporin-11; Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain . In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway . Plays a role by maintaining an environment suitable for translation or protein foldings in the ER lumen namely by participating to the PKD1 glycosylation processing resulting in regulation of PKD1 membrane trafficking thereby preventing the accumulation of unfolding protein in ER (By similarity). Plays a role in the proximal tubule function by regulating its endosomal acidification (By similarity). May play a role in postnatal kidney development (By similarity). ECO:0000269|PubMed:24845055, ECO:0000269|PubMed:24918044,; Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.

Synonyms:  AQP11,  AQP11p,  hAQP11,  Q8NBQ7,  Q8NBQ7p ...

Linkouts:  STRING  Pharos  UniProt  OMIM