DISEASES

Disease-gene associations mined from literature

Literature on IPO9

IPO9 [ENSP00000354742]

Importin-9; Functions in nuclear protein import as nuclear transport receptor . Serves as receptor for nuclear localization signals (NLS) in cargo substrates . Is thought to mediate docking of the importin/substrate complex to the nuclear pore complex (NPC) through binding to nucleoporin and the complex is subsequently translocated through the pore by an energy requiring, Ran- dependent mechanism . At the nucleoplasmic side of the NPC, Ran binds to the importin, the importin/substrate complex dissociates and importin is re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran . The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus . Mediates the nuclear import of RPS7, RPL18A, RPL6, histone H2A, histone H2B and histone . Prevents the cytoplasmic aggregation of RPS7 and RPL18A by shielding exposed basic domains . Mediates the nuclear import of actin (By similarity).

Synonyms:  IPO9,  IPO9p,  hIPO9,  Q5SVH5,  Q96P70 ...

Linkouts:  STRING  Pharos  UniProt