DISEASES

Disease-gene associations mined from literature

Literature on MCMBP

MCMBP [ENSP00000353098]

Mini-chromosome maintenance complex-binding protein; Associated component of the MCM complex that acts as a regulator of DNA replication. Binds to the MCM complex during late S phase and promotes the disassembly of the MCM complex from chromatin, thereby acting as a key regulator of pre-replication complex (pre-RC) unloading from replicated DNA. Can dissociate the MCM complex without addition of ATP; probably acts by destabilizing interactions of each individual subunits of the MCM complex. Required for sister chromatid cohesion.

Synonyms:  MCMBP,  A0A0S2Z5P5,  Q9BTE3,  Q9BTE3p,  hQ9BTE3 ...

Linkouts:  STRING  Pharos  UniProt