DISEASES

Disease-gene associations mined from literature

Literature on JPT1

JPT1 [ENSP00000348316]

Jupiter microtubule associated homolog 1, N-terminally processed; Modulates negatively AKT-mediated GSK3B signaling . Induces CTNNB1 'Ser-33' phosphorylation and degradation through the suppression of the inhibitory 'Ser-9' phosphorylation of GSK3B, which represses the function of the APC:CTNNB1:GSK3B complex and the interaction with CDH1/E-cadherin in adherent junctions . Plays a role in the regulation of cell cycle and cell adhesion (PubMed:25169422, PubMed:25450365). Has an inhibitory role on AR-signaling pathway through the induction of receptor proteosomal degradation . ECO:0000269|PubMed:22155408, ECO:0000269|PubMed:25169422,; Belongs to the JUPITER family.

Synonyms:  JPT1,  JPT1p,  hJPT1,  F2Z3M5,  J3KSH8 ...

Linkouts:  STRING  Pharos  UniProt