DISEASES

Disease-gene associations mined from literature

Literature on FNBP1L

FNBP1L [ENSP00000271234]

Formin-binding protein 1-like; Required to coordinate membrane tubulation with reorganization of the actin cytoskeleton during endocytosis. May bind to lipids such as phosphatidylinositol 4,5-bisphosphate and phosphatidylserine and promote membrane invagination and the formation of tubules. Also promotes CDC42-induced actin polymerization by activating the WASL/N-WASP-WASPIP/WIP complex, the predominant form of WASL/N-WASP in cells. Actin polymerization may promote the fission of membrane tubules to form endocytic vesicles. Essential for autophagy of intracellular bacterial pathogens; Belongs to the FNBP1 family.

Synonyms:  FNBP1L,  FNBP1Lp,  hFNBP1L,  A0A075B6Q2,  Q5T0N5 ...

Linkouts:  STRING  Pharos  UniProt  OMIM