DISEASES

Disease-gene associations mined from literature

Literature on ARFGEF3

ARFGEF3 [ENSP00000251691]

Brefeldin A-inhibited guanine nucleotide-exchange protein 3; Participates in the regulation of systemic glucose homeostasis, where it negatively regulates insulin granule biogenesis in pancreatic islet beta cells (By similarity). Also regulates glucagon granule production in pancreatic alpha cells (By similarity). Inhibits nuclear translocation of the transcriptional coregulator PHB2 and may enhance estrogen receptor alpha (ESR1) transcriptional activity in breast cancer cells .

Synonyms:  ARFGEF3,  ARFGEF3p,  hARFGEF3,  Q5TH69,  Q5TH69p ...

Linkouts:  STRING  Pharos  UniProt