DISEASES

Disease-gene associations mined from literature

Literature on SLC7A2

SLC7A2 [ENSP00000004531]

Cationic amino acid transporter 2; Functions as permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine); the affinity for its substrates differs between isoforms created by alternative splicing. Isoform 1 functions as permease that mediates the transport of the cationic amino acids (arginine, lysine and ornithine), and it has much higher affinity for arginine than isoform 2. Isoform 2 functions as low-affinity, high capacity permease involved in the transport of the cationic amino acids (arginine, lysine and ornithine) . May play a role in classical or alternative activation of macrophages via its role in arginine transport. ; Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.

Synonyms:  SLC7A2,  SLC7A2p,  hSLC7A2,  A0A1W2PR06,  P52569 ...

Linkouts:  STRING  Pharos  UniProt  OMIM