DISEASES

Disease-gene associations mined from literature

Literature on ELOVL4

ELOVL4 [ENSP00000358831]

Elongation of very long chain fatty acids protein 4; Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that catalyzes the synthesis of very long chain saturated (VLC-SFA) and polyunsaturated (PUFA) fatty acids that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development; Belongs to the ELO family. ELOVL4 subfamily.

Synonyms:  ELOVL4,  ELOVL4p,  hELOVL4,  Q9GZR5,  Q9GZR5p ...

Linkouts:  STRING  Pharos  UniProt  OMIM