DISEASES

Disease-gene associations mined from literature

Literature on EPHX2

EPHX2 [ENSP00000430269]

Bifunctional epoxide hydrolase 2; Bifunctional enzyme . The C-terminal domain has epoxide hydrolase activity and acts on epoxides (alkene oxides, oxiranes) and arene oxides (PubMed:12869654, PubMed:12574510, PubMed:22798687). Plays a role in xenobiotic metabolism by degrading potentially toxic epoxides (By similarity). Also determines steady- state levels of physiological mediators (PubMed:12869654, PubMed:12574510, PubMed:22798687). The N-terminal domain has lipid phosphatase activity, with the highest activity towards threo-9,10- phosphonooxy-hydroxy-octadecanoic acid, followed by erythro-9,10- phosphonooxy-hydroxy-octadecanoic acid, 12-phosphonooxy-octadec-9Z- enoic acid and 12-phosphonooxy-octadec-9E-enoic acid . ECO:0000269|PubMed:12574510, ECO:0000269|PubMed:12869654,

Synonyms:  EPHX2,  EPHX2p,  hEPHX2,  E5RFH6,  E5RFU2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM