DISEASES

Disease-gene associations mined from literature

Literature on DTX4

DTX4 [ENSP00000227451]

E3 ubiquitin-protein ligase DTX4; Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity). Functions as a ubiquitin ligase protein in vivo, mediating 'Lys48'-linked polyubiquitination and promoting degradation of TBK1, targeting to TBK1 requires interaction with NLRP4.

Synonyms:  DTX4,  DTX4p,  hDTX4,  Q9Y2E6,  Q9Y2E6p ...

Linkouts:  STRING  Pharos  UniProt