DISEASES

Disease-gene associations mined from literature

Literature on BRMS1

BRMS1 [ENSP00000396052]

Breast cancer metastasis-suppressor 1; Transcriptional repressor. Down-regulates transcription activation by NF-kappa-B by promoting the deacetylation of RELA at 'Lys-310'. Promotes HDAC1 binding to promoter regions. Down-regulates expression of anti-apoptotic genes that are controlled by NF-kappa-B. Promotes apoptosis in cells that have inadequate adherence to a substrate, a process called anoikis, and may thereby inhibit metastasis. May be a mediator of metastasis suppression in breast carcinoma.

Synonyms:  BRMS1,  BRMS1p,  hBRMS1,  E9PJF5,  E9PPD1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM