DISEASES

Disease-gene associations mined from literature

Literature on KDM4A

KDM4A [ENSP00000361473]

Lysine-specific demethylase 4A; Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code . Does not demethylate histone H3 'Lys- 4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively.

Synonyms:  KDM4A,  KDM4Ap,  hKDM4A,  A0A2R8Y7L1,  A0A2R8YDF7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM