DISEASES

Disease-gene associations mined from literature

Literature on NSD3

NSD3 [ENSP00000313983]

Histone-lysine N-methyltransferase NSD3; Histone methyltransferase. Preferentially dimethylates 'Lys- 4' and 'Lys-27' of histone H3 forming H3K2me2 and H3K27me2. H3 'Lys-4' methylation represents a specific tag for epigenetic transcriptional activation, while 'Lys-27' is a mark for transcriptional repression. ; Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.

Synonyms:  NSD3,  NSD3p,  hNSD3,  E9PKA2,  E9PKL3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM