DISEASES

Disease-gene associations mined from literature

Literature on PHC3

PHC3 [ENSP00000420294]

Polyhomeotic-like protein 3; Component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones; it mediates monoubiquitination of histone H2A 'Lys-119', rendering chromatin heritably changed in its expressibility.

Synonyms:  PHC3,  PHC3p,  hPHC3,  B4DTC4,  C9J6H0 ...

Linkouts:  STRING  Pharos  UniProt