DISEASES

Disease-gene associations mined from literature

Literature on NOXO1

NOXO1 [ENSP00000380450]

NADPH oxidase organizer 1; Constitutively potentiates the superoxide-generating activity of NOX1 and NOX3 and is required for the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. Isoform 3 is more potent than isoform 1 in activating NOX3. Together with NOXA1, may also substitute to NCF1/p47phox and NCF2/p67phox in supporting the phagocyte NOX2/gp91phox superoxide-generating activity. ECO:0000269|PubMed:15326186, ECO:0000269|PubMed:15824103, ECO:0000269|PubMed:15949904, ECO:0000269|PubMed:16329988,

Synonyms:  NOXO1,  NOXO1p,  hNOXO1,  H3BN18,  Q8NFA2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM