Literature on ZUP1
ZUP1 [ENSP00000357565]
Zinc finger-containing ubiquitin peptidase 1; Deubiquitinase with endodeubiquitinase activity that specifically interacts with and cleaves 'Lys-63'-linked long polyubiquitin chains. Shows only weak activity against 'Lys-11' and 'Lys-48'-linked chains (PubMed:29576528, PubMed:29563501, PubMed:29476094). Plays an important role in genome stability pathways, functioning to prevent spontaneous DNA damage and also promote cellular survival in response to exogenous DNA damage (PubMed:29576528, PubMed:29576527). Modulates the ubiquitination status of replication protein A (RPA) complex proteins in response to replication stress . ECO:0000269|PubMed:29563501, ECO:0000269|PubMed:29576527,
Synonyms: ZUP1, ZUP1p, hZUP1, A0A0S2Z644, Q96AP4 ...