DISEASES

Disease-gene associations mined from literature

Literature on PDE9A

PDE9A [ENSP00000291539]

High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A; Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. Highly specific: compared to other members of the cyclic nucleotide phosphodiesterase family, has the highest affinity and selectivity for cGMP . Specifically regulates natriuretic-peptide-dependent cGMP signaling in heart, acting as a regulator of cardiac hypertrophy in myocytes and muscle. Does not regulate nitric oxide-dependent cGMP in heart . Additional experiments are required to confirm whether its ability to hydrolyze natriuretic-peptide-dependent cGMP is specific to heart or is a general feature of the protein (Probable). In brain, involved in cognitive function, such as learning and long-term memory (By similarity). ECO:0000269|PubMed:18757755, ECO:0000269|PubMed:21483814,

Synonyms:  PDE9A,  PDE9Ap,  hPDE9A,  A0A0S2Z475,  A0A0S2Z4A3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM