DISEASES

Disease-gene associations mined from literature

Literature on PKMYT1

PKMYT1 [ENSP00000262300]

Membrane-associated tyrosine- and threonine-specific cdc2-inhibitory kinase; Acts as a negative regulator of entry into mitosis (G2 to M transition) by phosphorylation of the CDK1 kinase specifically when CDK1 is complexed to cyclins. Mediates phosphorylation of CDK1 predominantly on 'Thr-14'. Also involved in Golgi fragmentation. May be involved in phosphorylation of CDK1 on 'Tyr-15' to a lesser degree, however tyrosine kinase activity is unclear and may be indirect. May be a downstream target of Notch signaling pathway during eye development. ; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.

Synonyms:  PKMYT1,  PKMYT1p,  hPKMYT1,  A6NHV6,  B4DZM6 ...

Linkouts:  STRING  Pharos  UniProt  OMIM