DISEASES

Disease-gene associations mined from literature

Literature on HES1

HES1 [ENSP00000232424]

Transcription factor HES-1; Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1. Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'- CANNTG-3' with low affinity (By similarity). May play a role in a functional FA core complex response to DNA cross-link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage.

Synonyms:  HES1,  HES1p,  hHES1,  Q14469,  Q14469p ...

Linkouts:  STRING  Pharos  UniProt  OMIM