DISEASES

Disease-gene associations mined from literature

Literature on MRVI1

MRVI1 [ENSP00000412130]

Protein MRVI1; Plays a role as NO/PRKG1-dependent regulator of IP3-induced calcium release; its phosphorylation by PRKG1 inhibits bradykinin and IP3-induced calcium release from intracellular stores. Recruits PRKG1 to the endoplasmic reticulum and may mediate the assembly of PRKG1 and ITPR1 in a macrocomplex. Involved in PRKG1 signaling cascade leading to inhibition of platelet activation and aggregation. Mediates also NO- dependent inhibition of calcium signaling in gastrointestinal smooth muscle contributing to NO-dependent relaxation.

Synonyms:  MRVI1,  MRVI1p,  hMRVI1,  E9PJ61,  E9PNK7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM