DISEASES

Disease-gene associations mined from literature

Literature on FSCN1

FSCN1 [ENSP00000371798]

Fascin; Actin-binding protein that contains 2 major actin binding sites . Organizes filamentous actin into parallel bundles (PubMed:20393565, PubMed:21685497, PubMed:23184945). Plays a role in the organization of actin filament bundles and the formation of microspikes, membrane ruffles, and stress fibers . Important for the formation of a diverse set of cell protrusions, such as filopodia, and for cell motility and migration . Mediates reorganization of the actin cytoskeleton and axon growth cone collapse in response to NGF . ECO:0000269|PubMed:20393565, ECO:0000269|PubMed:21685497, ECO:0000269|PubMed:22155786, ECO:0000269|PubMed:23184945,

Synonyms:  FSCN1,  FSCN1p,  hFSCN1,  A0A0A0MSB2,  A0A384MEG1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM