DISEASES

Disease-gene associations mined from literature

Literature on LIN28B

LIN28B [ENSP00000344401]

Protein lin-28 homolog B; Suppressor of microRNA (miRNA) biogenesis, including that of let-7 and possibly of miR107, miR-143 and miR-200c. Binds primary let-7 transcripts (pri-let-7), including pri-let-7g and pri-let-7a-1, and sequester them in the nucleolus, away from the microprocessor complex, hence preventing their processing into mature miRNA . Does not act on pri-miR21 . The repression of let-7 expression is required for normal development and contributes to maintain the pluripotent state of embryonic stem cells by preventing let-7-mediated differentiation. When overexpressed, recruits ZCCHC11/TUT4 uridylyltransferase to pre-let-7 transcripts, leading to their terminal uridylation and degradation . This activity might not be relevant in vivo, as LIN28B-mediated inhibition of let-7 miRNA maturation appears to be ZCCHC11-independent . Interaction with target pre-miRNAs occurs via an 5'- GGAG-3' motif in the pre-miRNA terminal loop. Mediates MYC-induced let- 7 repression (By similarity). When overexpressed, isoform 1 stimulates growth of the breast adenocarcinoma cell line MCF-7. Isoform 2 has no effect on cell growth. ECO:0000269|PubMed:16971064, ECO:0000269|PubMed:18951094,; Belongs to the lin-28 family.

Synonyms:  LIN28B,  LIN28Bp,  hLIN28B,  A0A1B0GTK2,  A0A1B0GVD3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM