DISEASES

Disease-gene associations mined from literature

Literature on SMAD1

SMAD1 [ENSP00000305769]

Mothers against decapentaplegic homolog 1; Transcriptional modulator activated by BMP (bone morphogenetic proteins) type 1 receptor kinase. SMAD1 is a receptor- regulated SMAD (R-SMAD). SMAD1/OAZ1/PSMB4 complex mediates the degradation of the CREBBP/EP300 repressor SNIP1. May act synergistically with SMAD4 and YY1 in bone morphogenetic protein (BMP)- mediated cardiac-specific gene expression. ; Belongs to the dwarfin/SMAD family.

Synonyms:  SMAD1,  SMAD1p,  hSMAD1,  A0A1D5RMR4,  D6RAY1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM