DISEASES

Disease-gene associations mined from literature

Literature on TIAM1

TIAM1 [ENSP00000286827]

T-lymphoma invasion and metastasis-inducing protein 1; Modulates the activity of RHO-like proteins and connects extracellular signals to cytoskeletal activities. Acts as a GDP- dissociation stimulator protein that stimulates the GDP-GTP exchange activity of RHO-like GTPases and activates them. Activates RAC1, CDC42, and to a lesser extent RHOA. Required for normal cell adhesion and cell migration.

Synonyms:  TIAM1,  TIAM1p,  hTIAM1,  A0A1B0GW57,  A0A2X0TW27 ...

Linkouts:  STRING  Pharos  UniProt  OMIM