Literature on GUK1
GUK1 [ENSP00000355689]
Guanylate kinase; Catalyzes the phosphorylation of GMP to GDP. Essential enzyme for recycling GMP and indirectly, cyclic GMP (cGMP) . Involved in the cGMP metabolism in photoreceptors (By similarity). It may also have a role in the survival and growth progression of some tumors . In addition to its physiological role, GUK1 is essential for convert prodrugs used for the treatment of cancers and viral infections into their pharmacologically active metabolites, most notably acyclovir, ganciclovir, and 6-thioguanine and its closely related analog 6-mercaptopurine (PubMed:197968, PubMed:6248551, PubMed:6306664). ECO:0000269|PubMed:197968, ECO:0000269|PubMed:31201273,; Belongs to the guanylate kinase family.
Synonyms: GUK1, GUK1p, hGUK1, B1ANG9, B1ANH0 ...