DISEASES

Disease-gene associations mined from literature

Literature on ACAD9

ACAD9 [ENSP00000312618]

Complex I assembly factor ACAD9, mitochondrial; As part of the MCIA complex, primarily participates to the assembly of the mitochondrial complex I and therefore plays a role in oxidative phosphorylation . This moonlighting protein has also a dehydrogenase activity toward a broad range of substrates with greater specificity for long-chain unsaturated acyl-CoAs (PubMed:12359260, PubMed:16020546, PubMed:21237683, PubMed:24158852). However, in vivo, it does not seem to play a primary role in fatty acid oxidation . In addition, the function in complex I assembly is independent of the dehydrogenase activity of the protein . ECO:0000269|PubMed:20816094, ECO:0000269|PubMed:21237683,

Synonyms:  ACAD9,  ACAD9p,  hACAD9,  D6R9Z3,  D6RCD8 ...

Linkouts:  STRING  Pharos  UniProt  OMIM