DISEASES

Disease-gene associations mined from literature

Literature on USP22

USP22 [ENSP00000261497]

Ubiquitin carboxyl-terminal hydrolase 22; Histone deubiquitinating component of the transcription regulatory histone acetylation (HAT) complex SAGA. Catalyzes the deubiquitination of both histones H2A and H2B, thereby acting as a coactivator. Recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation and cell cycle progression.

Synonyms:  USP22,  USP22p,  hUSP22,  J3QRV6,  J3QS30 ...

Linkouts:  STRING  Pharos  UniProt  OMIM