DISEASES

Disease-gene associations mined from literature

Literature on ARL1

ARL1 [ENSP00000261636]

ADP-ribosylation factor-like protein 1; GTP-binding protein that recruits several effectors, such as golgins, arfaptins and Arf-GEFs to the trans-Golgi network, and modulates their functions at the Golgi complex (PubMed:9624189, PubMed:21239483, PubMed:27436755, PubMed:22679020, PubMed:27373159). Plays thereby a role in a wide range of fundamental cellular processes, including cell polarity, innate immunity, or protein secretion mediated by arfaptins, which were shown to play a role in maintaining insulin secretion from pancreatic beta cells . ECO:0000269|PubMed:22981988, ECO:0000269|PubMed:27373159,

Synonyms:  ARL1,  ARL1p,  hARL1,  B4DZG7,  F8VP63 ...

Linkouts:  STRING  Pharos  UniProt  OMIM