DISEASES

Disease-gene associations mined from literature

Literature on TRIAP1

TRIAP1 [ENSP00000449795]

TP53-regulated inhibitor of apoptosis 1; Involved in the modulation of the mitochondrial apoptotic pathway by ensuring the accumulation of cardiolipin (CL) in mitochondrial membranes. In vitro, the TRIAP1:PRELID1 complex mediates the transfer of phosphatidic acid (PA) between liposomes and probably functions as a PA transporter across the mitochondrion intermembrane space to provide PA for CL synthesis in the inner membrane . Likewise, the TRIAP1:PRELID3A complex mediates the transfer of phosphatidic acid (PA) between liposomes (in vitro) and probably functions as a PA transporter across the mitochondrion intermembrane space (in vivo) . Mediates cell survival by inhibiting activation of caspase-9 which prevents induction of apoptosis ; Belongs to the TRIAP1/MDM35 family.

Synonyms:  TRIAP1,  TRIAP1p,  hTRIAP1,  O43715,  O43715p ...

Linkouts:  STRING  Pharos  UniProt  OMIM