DISEASES

Disease-gene associations mined from literature

Literature on HTATIP2

HTATIP2 [ENSP00000392985]

Oxidoreductase HTATIP2; Oxidoreductase required for tumor suppression. NAPDH-bound form inhibits nuclear import by competing with nuclear import substrates for binding to a subset of nuclear transport receptors. May act as a redox sensor linked to transcription through regulation of nuclear import. Isoform 1 is a metastasis suppressor with proapoptotic as well as antiangiogenic properties. Isoform 2 has an antiapoptotic effect.

Synonyms:  HTATIP2,  HTATIP2p,  hHTATIP2,  E9PI87,  Q9BUP3 ...

Linkouts:  STRING  Pharos  UniProt  OMIM