DISEASES

Disease-gene associations mined from literature

Literature on ITGA8

ITGA8 [ENSP00000367316]

Integrin alpha-8 heavy chain; Integrin alpha-8/beta-1 functions in the genesis of kidney and probably of other organs by regulating the recruitment of mesenchymal cells into epithelial structures. It recognizes the sequence R-G-D in a wide array of ligands including TNC, FN1, SPP1 TGFB1, TGFB3 and VTN. NPNT is probably its functional ligand in kidney genesis. Neuronal receptor for TNC it mediates cell-cell interactions and regulates neurite outgrowth of sensory and motor neurons.

Synonyms:  ITGA8,  ITGA8p,  hITGA8,  P53708,  P53708p ...

Linkouts:  STRING  Pharos  UniProt  OMIM