DISEASES

Disease-gene associations mined from literature

Literature on MINPP1

MINPP1 [ENSP00000361064]

Multiple inositol polyphosphate phosphatase 1; Acts as a phosphoinositide 5- and phosphoinositide 6- phosphatase and regulates cellular levels of inositol pentakisphosphate (InsP5) and inositol hexakisphosphate (InsP6). Also acts as a 2,3- bisphosphoglycerate 3-phosphatase, by mediating the dephosphorylation of 2,3-bisphosphoglycerate (2,3-BPG) to produce phospho-D-glycerate without formation of 3-phosphoglycerate. May play a role in bone development (endochondral ossification). May play a role in the transition of chondrocytes from proliferation to hypertrophy (By similarity); Belongs to the histidine acid phosphatase family. MINPP1 subfamily.

Synonyms:  MINPP1,  MINPP1p,  hMINPP1,  Q9UNW1,  Q9UNW1p ...

Linkouts:  STRING  Pharos  UniProt  OMIM