DISEASES

Disease-gene associations mined from literature

Literature on IFNAR2

IFNAR2 [ENSP00000343957]

Interferon alpha/beta receptor 2; Associates with IFNAR1 to form the type I interferon receptor. Receptor for interferons alpha and beta. Involved in IFN- mediated STAT1, STAT2 and STAT3 activation . Isoform 1 and isoform 2 are directly involved in signal transduction due to their association with the TYR kinase, JAK1 (PubMed:8181059, PubMed:7665574, PubMed:7759950). Isoform 3 is a potent inhibitor of type I IFN receptor activity . ECO:0000269|PubMed:11682488, ECO:0000269|PubMed:12105218, ECO:0000269|PubMed:26424569, ECO:0000269|PubMed:7665574,

Synonyms:  IFNAR2,  IFNAR2p,  hIFNAR2,  C9JCU0,  C9JM33 ...

Linkouts:  STRING  Pharos  UniProt  OMIM