DISEASES

Disease-gene associations mined from literature

Literature on SIGLEC1

SIGLEC1 [ENSP00000341141]

Sialoadhesin; Acts as an endocytic receptor mediating clathrin dependent endocytosis. Macrophage-restricted adhesion molecule that mediates sialic-acid dependent binding to lymphocytes, including granulocytes, monocytes, natural killer cells, B-cells and CD8 T-cells. Preferentially binds to alpha-2,3-linked sialic acid (By similarity). Binds to SPN/CD43 on T-cells (By similarity). May play a role in hemopoiesis.

Synonyms:  SIGLEC1,  SIGLEC1p,  hSIGLEC1,  H7C0M6,  Q9BZZ2 ...

Linkouts:  STRING  Pharos  UniProt  OMIM