DISEASES

Disease-gene associations mined from literature

Literature on IQGAP1

IQGAP1 [ENSP00000268182]

Ras GTPase-activating-like protein IQGAP1; Plays a crucial role in regulating the dynamics and assembly of the actin cytoskeleton. Binds to activated CDC42 but does not stimulate its GTPase activity. It associates with calmodulin. Could serve as an assembly scaffold for the organization of a multimolecular complex that would interface incoming signals to the reorganization of the actin cytoskeleton at the plasma membrane. May promote neurite outgrowth . May play a possible role in cell cycle regulation by contributing to cell cycle progression after DNA replication arrest .

Synonyms:  IQGAP1,  IQGAP1p,  hIQGAP1,  A0A024RC65,  A0A087WWP1 ...

Linkouts:  STRING  Pharos  UniProt  OMIM