DISEASES

Disease-gene associations mined from literature

Literature on SHFL

SHFL [ENSP00000253110]

Shiftless antiviral inhibitor of ribosomal frameshifting protein; Inhibits programmed -1 ribosomal frameshifting (-1PRF) of a variety of mRNAs from viruses, such as HIV1, and cellular genes, such as PEG10. Interacts with the -1PRF signal of target mRNA and translating ribosomes and causes premature translation termination at the frameshifting site . Regulates HIV1 GAG-POL expression by inhibiting -1PRF . Exhibits antiviral activity against dengue virus (DENV) and can inhibit the replication of all DENV serotypes. May block the protein translation of DENV RNA via its association with cellular mRNA-binding proteins and viral RNA. Can also limit the replication of hepatitis C virus (HCV), West Nile virus (WNV), Chikungunya virus (CHIKV), herpes simplex virus type 1 (HHV-1) and human adenovirus . Binds nucleic acids with a higher affinity for ssRNA and ssDNA than for dsDNA ; Belongs to the SHFL family.

Synonyms:  SHFL,  K7ELT7,  K7EML3,  K7EMS9,  K7EP02 ...

Linkouts:  STRING  Pharos  UniProt