DISEASES

Disease-gene associations mined from literature

Literature on C4BPB

C4BPB [ENSP00000243611]

C4b-binding protein beta chain; Controls the classical pathway of complement activation. It binds as a cofactor to C3b/C4b inactivator (C3bINA), which then hydrolyzes the complement fragment C4b. It also accelerates the degradation of the C4bC2a complex (C3 convertase) by dissociating the complement fragment C2a. It also interacts with anticoagulant protein S and with serum amyloid P component. The beta chain binds protein S.

Synonyms:  C4BPB,  C4BPBp,  hC4BPB,  P20851,  Q5VVQ7 ...

Linkouts:  STRING  Pharos  UniProt  OMIM