DISEASES

Disease-gene associations mined from literature

Literature on TRPC3

TRPC3 [ENSP00000368966]

Short transient receptor potential channel 3; Thought to form a receptor-activated non-selective calcium permeant cation channel. Probably is operated by a phosphatidylinositol second messenger system activated by receptor tyrosine kinases or G- protein coupled receptors. Activated by diacylglycerol (DAG) in a membrane-delimited fashion, independently of protein kinase C, and by inositol 1,4,5-triphosphate receptors (ITPR) with bound IP3. May also be activated by internal calcium store depletion.

Synonyms:  TRPC3,  TRPC3p,  hTRPC3,  D6R902,  D6RC49 ...

Linkouts:  STRING  Pharos  UniProt  OMIM